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& Shiota, K
[1] Whilst Wegovy primarily targets metabolic pathways, GLP-1 receptors are also present in various brain regions, including some associated with mood regulation, though a direct link to emotional processing remains hypothetical rather than proven
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A positive response was considered quick retraction of the head or scratching of the face with the ipsilateral forepaw
Results showed combination therapy achieved 83% clinical response versus 61% for golimumab monotherapy and 75% for guselkumab monotherapy, with AEs including UC flares, respiratory infections, and headache but no deaths or malignancies during the 12-week induction period, demonstrating superior efficacy of dual biologic approach over single-agent treatment ( An ongoing Phase 2b randomized, double-blind trial investigates the golimumab/guselkumab combination therapy (DUET-UC Study, NCT05242484) at various dose levels compared to placebo and individual monotherapies in 577 patients with moderately to severely active UC who failed prior advanced therapies
It is well-tolerated in animal and early clinical studies, even at multi-milligram doses [12]
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