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This decline doesnt happen all at once, but slowly, often unnoticed at first
This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Yang et al., 2014)
It is important to note that while prednisone can provide significant relief from symptoms, it may also come with a range of side effects, especially with long-term use
Sleep, stress, energy and confidence may all shift at the same time
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