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In addition to promoting weight loss up to 20.9% in clinical trials, tirzepatide: Reduces visceral fat and improves insulin sensitivity-even in non-diabetic individuals Inhibits inflammatory cytokines like TNF- and IL-6 Shifts immune profiles toward anti-inflammatory M2 macrophages Stimulates thermogenesis by boosting UCP1 expression in brown adipose tissue Reduces fibrosis by modulating extracellular matrix remodeling These effects mirror many of the pathological mechanisms at play in lipedema
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The scientific community is actively exploring other peptides for their potential in nerve regeneration and pain management
However, those already on blood pressure medications should be monitored closely, as GLP-1-induced blood pressure reductions could necessitate antihypertensive dose adjustments to prevent hypotension or orthostatic symptoms
Rare serious side effects include pancreatitis and gallbladder issues
doi: 10.1038/s41467-020-19173-2 4 LivreAde la FouchardireCSamalinEBenoistSPhelipJMAndrTet al
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