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How Common Is Diarrhoea During Treatment Diarrhoea was reported in a dose-dependent manner in Phase 2 trials

Hurtado I, Robles C, Peir S, Garca-Sempere A, Sanflix-Gimeno G

Nat Med 2013 , 19 , 576585

Randomized controlled trials of AOMs conducted in population for at least 4 weeks and followed for 4 or more weeks after discontinuation were included

Key risks include worsened gastrointestinal side effects (nausea, vomiting), hypoglycaemia (particularly in patients taking insulin or sulfonylureas), dehydration, inadequate nutritional intake, and potential exacerbation of pancreatitis or gallbladder problems

Theyre not FDA-approved and are prepared according to a prescription for an individual patient