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Lonza) was used for all other KAT6A mutations to increase the rate of HDR, following a modified Alt-R CRISPR-Cas9 System protocol (IDT)

For the fMRI substudy, patients attended 2 additional visits and underwent an fMRI session during the last treatment week in each treatment phase

GLP-1RA/tesaglitazar does not differ from the pharmacokinetically matched GLP-1RA in GLP-1R signalling, but shows GLP-1R-dependent PPAR-retinoic acid receptor heterodimerization and enhanced improvements of body weight, food intake and glucose metabolism relative to the GLP-1RA or tesaglitazar alone in obese male mice

Lee TH, Yau S (2020) From obesity to hippocampal neurodegeneration: pathogenesis and non-pharmacological interventions

As always, its crucial to consult with a licensed healthcare professional, like Dr