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The Neh1 domain contains a bZIP binding motif responsible for the formation of a heterodimer with small musculoaponeurotic fibrosarcoma (sMaf) proteins and mediates the binding to ARE sequences, within the promoter of NRF2 target genes [152]

Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al

Accessed via Pickart and Margolina 2018 analysis (PMID 29987191)

Further studies with human participants are needed to understand the underlying mechanisms in humans

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