Glucose is actively reabsorbed in the proximal convoluted tubule via the Na + -glucose transporter 2 (SGLT2), which couples the transport of the sugar with that of Na + following its electrochemical gradient created by the Na + /K + ATPase on the basolateral membrane of the tubular cells (see Figure 3B)
This gradual approach is designed to help reduce side effects, like nausea or digestive discomfort, and improve how well you tolerate the medication long-term
The results of the phase 3 clinical trial of retatrutide are eagerly awaited, as it is expected that over a longer time period its efficacy in weight loss will be even greater
We celebrated our 500th episode of the NutritionFacts Podcast in July 2026
Time-to-event analyses showed a lower risk of hospitalization and better persistence on advanced Crohns therapies among patients receiving GLP-1 treatment (HR 0.74)
Bloem BR, Okun MS, Klein C