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doi:10.1038/s41598-024-77218-8 66

Slower Onset: Effects may take longer to notice, especially in people with severe depletion

Clear communication about when to contact the healthcare provider versus when to seek emergency care is essential for patient safety

Semaglutide is a single-target GLP-1 agonist that produced about 14.9% weight loss at 68 weeks in the STEP-1 trial

Although the single doses secrete the rapid GH peaks, measurable rises of IGF-1 in serum require sustained and repeated dosing

Until such data are available, supplementation should be tailored individually and administered under the guidance of healthcare professionals