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R After glutathione conjugation, the conjugate is further processed through the mercapturic acid pathway : gamma-glutamyl transpeptidase removes glutamate, then a dipeptidase removes glycine, leaving a cysteine conjugate that is N-acetylated to form a mercapturic acid (N-acetylcysteine conjugate)

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Collectively, these advances have expanded the therapeutic landscape to include immunomodulation, gene regulation, and physical modalities such as photothermal and sonodynamic therapies, offering new avenues to address resistance and metastasis

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