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Mogelijk spelen geadviseerde dosisverlagingen van insulines bij combinatie met GLP-1-agonisten of SGLT-2-remmers hierin een rol

A meta-analysis of adults with knee OA and obesity found that a 5% to 10% weight loss significantly improved pain, self-reported disability, and physical quality of life (Chu et al., 2018)

Tirzepatide does activate GLP-1 receptors, but it is not considered a traditional GLP-1 receptor agonist because it also activates GIP receptors

GLP-1 receptor agonists like Retatrutide suppress ghrelin release, providing lasting appetite control that diet and exercise alone cannot match

Doctors may decide to adjust the dose, switch medications, or recommend ways to manage the pain