While this body of evidence is highly encouraging, it is important to note that these findings are derived from studies with considerable methodological heterogeneity, a limitation that will be addressed in the Discussion
Long-term weight loss and weight-loss maintenance strategies
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Aggressive protocols make sense for acute needs
The guidelines warn, however, that GLP-1 receptor agonist therapy is not indicated for all patients and should be used with caution in patients with a history of significant gastrointestinal disease, such as a diagnosis of gastroparesis, due to a possible exacerbation of the condition with incretin mimetic therapy
7, 8, 9, 10 In recent years, there have been numerous discussions about potential problems with incretin used for diabetes treatment as it may induce thyroid and/or pancreas pathologies