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Tissue perfusion and sexual function pathways A case report of female anorgasmia and hypoarousal temporally related to GLP-1 agonist use (including semaglutide after a switch from liraglutide) proposed mechanisms including smooth-muscle vasoconstriction with reduced genital blood flow and central neurotransmitter pathway effects (hypothalamic signalling)

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These limitations can be more appropriately addressed in future systematic reviews with meta-analyses