*Correspondence: Hui Chen [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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They are subsequently degraded in the proteasome and translocated into the nucleus where they bind to specific DNA sequences and initiate the transcription of target genes involved in the immune response, inflammation (e.g., tumor necrosis factor (TNF)-, ILs 1 and 6, prostaglandins), chemotaxis (e.g., IL-8), cell adhesion (intercellular adhesion molecule-1, vascular adhesion molecule-1), growth regulation, and apoptosis resistance
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