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Steroids should be used with caution in nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess or other pyogenic infection as well as in diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer

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American Society of Health-System Pharmacists

For the coated tablet form, the patient should take the tablet with plain water, either before or after meals, and must not crush or chew the tablet