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For comparison, normal apoE / mice were treated with saline by the same protocol

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[6] The core AOD9604 studies do not provide a validated comprehensive gene-expression signature covering HSL, ATGL, CPT1, MCAD, PGC-1alpha, UCP1, leptin, and adiponectin

Berberine administration is evidenced to improve cognitive impairment and neurological deficits and reduce brain edema in rodent models of TBI