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Most people see their most significant weight loss during the first month of treatment

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When the patient is on one medication and the pain is still unbearable, the second medicine may be started at a low dose and titrated up as the patient tolerates and as the pain decreases

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Special considerations : If you are planning pregnancy, the MHRA/EMC guidance states that Rybelsus should be discontinued at least 2 months before conception due to the long half-life of semaglutide