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Replacement treatment using human adiponectin may help identify therapeutic targets for preventing and treating metabolic diseases, including insulin resistance and type 2 diabetes (194)

Fully achieved reduction of severe lesions in the brain, heart, lungs, liver, kidneys, and gastrointestinal tract reduced thrombosis in both veins and arteries, peripherally and centrally, and fully abrogated intracranial (superior sagittal sinus), portal, and caval hypertension and aortal hypotension may be regarded as a proof of concept

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Current guidelines from the European Society of Cardiology and American Diabetes Association strongly endorse GLP-1 receptor agonists with proven cardiovascular benefit for patients with established atherosclerotic cardiovascular disease

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Biochemical Society transactions 41, 172179, doi: 10.1042/BST20120236 (2013)