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GIP agonism Adds the glucose-dependent insulinotropic polypeptide arm the second receptor in the dual-agonist family
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One of the fundamental principles of therapeutic drug development is confirmation of end-target engagement, measured most readily and ideally via serum biomarkers
Ruan S, et al
Whilst semaglutide is not primarily eliminated by the kidneys and does not directly damage renal tissue, certain side effectsespecially gastrointestinal symptomscan lead to dehydration and acute kidney injury if fluid intake is inadequate
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