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Endocrinology 142 , 18781888 (2001)

An experienced clinician will determine the combination based on the severity of tissue fragility: milder laxity or isolated painful joints might be treated with prolotherapy or PRP, whereas severe joint destruction or recurrent dislocations may warrant adding stem cell injections

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C1R mutations trigger constitutive complement 1 activation in periodontal EhlersDanlos syndrome