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2 Methods 2.1 Protocol registration This study was implemented according to a priori-written protocol registered in PROSPERO (CRD42022337099, registered 13 June 2022) and the reporting was followed by the PRISMA ( Table S1 )
doi: 10.1016/j.etap.2024.104201 125 ZhangYHuangHLuoCZhangXChenYYueFet al
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Weight loss medications like tirzepatide can potentially affect libido and sexual function through multiple indirect pathways, though there is no official direct link established between tirzepatide and increased libido in clinical trials or FDA labeling
Researchers hypothesize that semaglutides modulation of GLP-1 receptors indirectly dampens this dopaminergic hyperactivation in critical brain regions such as the nucleus accumbens
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