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Animal offspring exposed to spironolactone during late pregnancy exhibited changes in the reproductive tract, including dose-dependent decreases in weights of the ventral prostate and seminal vesicle in males, ovaries and uteri that were enlarged in females, and other indications of endocrine dysfunction that persisted into adulthood

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[PMID: 15357143] PubMed record related to this compound for laboratory literature review

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The American Heart Association recommends that only about 5% of your calories come from these foods