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Drug Interactions NAC-Drug Interactions NAC has several clinically relevant drug interactions [9][18]: Glutathione-Drug Interactions Fewer drug interactions have been specifically documented for oral glutathione supplements compared to NAC, likely because oral glutathione achieves lower systemic levels

The medication appears to have a favorable safety profile, with most side effects being mild and manageable

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It is the FDAs way of flagging a substance that may present significant safety risks when used in compounding