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The lower threshold (BMI 27) reflects that adipose tissue can become pathological even before Class I obesity is reached
Although the meta-analysis did not yield statistically significant results, both preclinical and clinical evidence suggest that antioxidant use represents a promising strategy to mitigate the adverse effects of acute high-altitude exposure
Sensitivity analyses were performed to assess the impact of the definition of MACE (three-point MACE [non-fatal myocardial infarction, non-fatal stroke and cardiovascular death] vs other MACE definitions), risk of bias, data source (electronic healthcare records vs other data sources) and method of adjusting for confounding (propensity scores or inverse probability of treatment weighting vs multivariable regression, restriction or matching)
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