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With injections: effects (e.g., radiance, reduced pigmentation) may appear after several sessions

While it is not clear how this translates to the kinetics of cAMP production in cells expressing individual receptors, the divergence in peptide responses across each receptor is consistent with the dynamic conformational differences that were observed structurally for individual AMYRs bound to distinct peptides

www.fda.gov/Drugs/DrugSafety/ 18