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Statistical analysis Data were statistically analyzed using SPSS (version 19.0.1, Chicago, Illinois, USA) for Windows

ATF4 resulted in the induction of heat shock protein 70 family protein 5 (HSPA5), which in turn bound GPX4 and protected against GPX4 protein degradation and subsequent lipid peroxidation (Zhu et al., 2017), and GSH-specific gamma-glutamylcyclotransferase 1 (CHAC1) degradation of GSH enhanced ferroptosis through GCN2-eIF2-ATF4-GPX4 pathway (Chen et al., 2017)

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This mapping helps identify your individual predisposition to GLP-1 response, allowing personalized dosing guidance beyond one-size-fits-all supplement recommendations