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Those with insulin resistance or who have not responded to other therapies may benefit from Zepbounds broader metabolic action

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Another network meta-analysis of RCTs, including participants with T2DM, found that GLP-1 RAs decreased the risk of non-fatal MI (Odds Ratio [OR] = 0.92, 95%CI = 0.850.99) when compared to placebo or standard care (Sattar et al., 2021)

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Retatrutide's treatment-specific effect above placebo was approximately 35 percentage points

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14, 223238 (Springer, 1996)

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