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These inhibitors not only prevent necroptotic cell death but also play a crucial role in suppressing NLRP3 inflammasome activation, thereby reducing neuroinflammation and neuronal damage in models of glutamate-induced excitotoxicity (113)
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The link is clear: a compromised gut barrier (leaky gut) allows inflammatory cytokines and lipopolysaccharides (LPS) to enter systemic circulation
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Free Radic Biol Med 88(Pt B):290301
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