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Furthermore, it was established that GSTP1 gene was demethylated and reactivated following exposure to green tea polyphenols in prostate cancer cells (Pandey et al., 2010)

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These findings suggest that MAPKAPK2 downregulation in vitiligo melanocytes is exacerbated under oxidative stress conditions, while its basal repression can be partially reversed by targeting DNA methylation, highlighting a potential contribution of epigenetic regulation to melanocyte vulnerability

Expert opinion Hunt et al 23 Data from randomized controlled trials and observational studies for parenteral treatment are lacking

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