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Starting metformin extended-release and titrating GLP-1 therapy slowly (typically over 46 weeks) minimizes tolerability issues and improves adherence

Maintain excellent hygiene practices

Ensuring the safety and effectiveness of the treatment is paramount

The lack of extensive longitudinal studies creates hesitation among some healthcare providers and regulatory bodies

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We have assessed various metabolic parameters after short and long exposure of clonal BRIN-BD11 -cells and rodent islets to the GLP-1R agonist Exendin-4 (50 nM)