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Asano et al
Wilding JP, Batterham RL, Calanna S, et al
severe infections or sepsis, irregular blood vessel surface (vasculitis, artificial heart valve), or, rarely, disseminated intravascular coagulation or DIC (a serious complication of overwhelming infections, traumas, burns, or pregnancy)
Insurance coverage for semaglutide is more established than tirzepatide given its longer market presence, though coverage for weight management specifically as opposed to diabetes remains inconsistent and often requires prior authorization
It is possible, but the quality of weight loss is significantly worse without resistance training, especially for HRT users whose muscle mass is already vulnerable