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While several CVOTs were performed with injectable GLP-1 RAs [46], the recent SOUL trial assessed the use of oral semaglutide, which was associated with a significantly lower risk of MACE than a placebo, without an increase in the incidence of serious adverse events, in patients with T2D and atherosclerotic cardiovascular disease (ASCVD), CKD, or both [71]

Unlike single-agonist peptides where one chart covers everything, retatrutide demands careful attention to reconstitution volumes, concentration math, and a structured escalation schedule that accounts for three separate receptor pathways

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This adds uncertainty, making generalized claims more difficult

Note: Wegovy tablets and orforglipron have been approved for use in the U.S