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4 Musculoskeletal disability In our cohort we observed significant variability in the severity of musculoskeletal symptoms and their effect on day-to-day function between the different probands and even within the same family

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Isotretinoin also has a number of other frequent adverse effects: Itchy, irritated skin Hair loss (temporary) Skin dryness Infections Rashes Discomfort in the bones and joints A Warning Even a single dosage of accutane before and after may be fatal to an unborn child

Results may take time, usually weeks or months