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The HADDOCK2.2 web server: user-friendly integrative modeling of biomolecular complexes

Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21

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PMID 26310692

Hypotheses include GIPR-mediated enhancement of GLP-1R sensitivity and independent adipose tissue effects of GIPR agonism

In the SURMOUNT-1 trial published in the New England Journal of Medicine (2022), GORD was reported in approximately 5 to 9% of participants across tirzepatide dose groups, compared with 1 to 2% in the placebo arm