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This makes obesity one of the leading risk factors for multimorbidity 2 , negatively impacting metabolic, cardiovascular (CV), mental and physical health, as well as mortality 3,4

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Proglucagon , a 160-residue peptide produced by the pancreas -cells and the small intestines K and L cells , undergoes selective posttranslational modifications to produce these essential incretin hormones

These products act through related but distinct pathways

The contribution margin income statement is covered in detail in Chapter 1