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Moreover, the inhibition of transforming growth factor beta (TGF-) signaling, which is an important profibrotic mechanism for activating fibroblasts and inducing extracellular matrix deposition, mediates the antifibrosis action (Rizvi et al

Discontinuation rates ranged from 8% to 27% depending on escalation strategy [35]

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If people with diabetes are missing doses, that could cause concerning effects on blood sugar levels, and the benefits to reduce heart disease risk or kidney disease are likely to be less, Low Wang said