This could theoretically attenuate the natriuretic effect of GLP-1 RAs
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However, both berberine and semaglutide have been shown in clinical trials to help cells respond better to insulin
Cynthia Maxwell MD, MBA, FRCSC, DABOM (Obesity Medicine), is the Medical Content Director of First Exposure, the Vice President, Medical Affairs & System Transformation and Lead Medical Executive at Womens College Hospital and Professor, Faculty of Medicine, Department of Obstetrics and Gynaecology and Division of Maternal Fetal Medicine at the University of Toronto
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As we have seen, semaglutide, a GLP-1 receptor agonist known for its efficacy in managing type 2 diabetes and obesity, may also impact hormonal balance, particularly in patients undergoing hormone replacement therapy (HRT)