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A 2025 systematic review encompassing 544 screened articles and 36 studies meeting inclusion criteria confirmed that BPC-157 consistently reduces inflammatory cytokines and improves structural and biomechanical outcomes across muscle, tendon, ligament, and bone injury models

On the other hand, the transcription factor Nrf2 (NF-E2 p45-related factor 2) regulates the expression of anti-inflammatory and antioxidant NADPH, NAD(P)H quinone oxidoreductase 1, glutathione peroxidase, ferritin, hemeoxygenase-1 (HO-1) and other detoxifying enzyme genes