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HFD impairs liver glutathione biosynthesis, vitamin D metabolism genes and genes associated with non-alcoholic fatty liver disease (NAFLD) Genes involved in the GSH biosynthesis pathway were significantly downregulated in the livers of mice fed an HFD compared to those of mice fed a healthy diet (controls) (Fig

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Genetic variations in these key enzymes may collectively contribute to elevated estrogen levels in uterine fibroid tissue by enhancing E 2 synthesis and altering the balance of E 2 metabolic pathways [Citation28,Citation29]

SULFONAMIDE ALLERGY Patients with a reported sulfonamide allergy are frequently encountered in clinical practice