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Table of Contents How Retatrutide Affects the Digestive System Bowel Changes Reported in Clinical Trials Why GLP-1 Receptor Agonists Can Alter Bowel Habits Managing Gastrointestinal Side Effects Safely When to Seek Medical Advice About Digestive Symptoms What Current Evidence and MHRA Guidance Says Frequently Asked Questions How Retatrutide Affects the Digestive System Retatrutide activates GLP-1 receptors throughout the gut, slowing gastric emptying and altering bowel motility