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As OCTN3 mediates sodium-independent carnitine transport and humans lack a functional ortholog of this protein, caution is warranted when extrapolating data on renal carnitine handling from rodent models to humans [78, 79]

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The Commission stopped short of recommending forced divestiture in its interim findings but has indicated that the final report will include structural remedies

In the T2DM patients, 4 weeks treatment with the DPP-IV inhibitor (LAF237) significantly increased basal and post-prandial active GLP-1 concentration by approximately 50 % relative to the placebo