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2 Beyond preventing unplanned pregnancies, OCPs offer additional benefits, such as alleviating menstrual discomfort, managing acne, and reducing the risk of ovarian and endometrial cancers

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Therefore, the analysis was performed using a random-effects model with the REML (Restricted Maximum Likelihood) estimator, which provides a more conservative and appropriate pooled effect when variability across studies is expected

4.5 Cardiovascular complications Given that cardiovascular damage is less severe among children with NS than in adults, we shall briefly explore its implications

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