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A comprehensive review of the family of very-long-chain fatty acid elongases: Structure, function, and implications in physiology and pathology

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when the intracellular Fe2+ overload exceeds the caching capacity of ferritin, and intracellular free iron generates ROS through the fenton reaction, and glutathione (GSH), one of the critically important antioxidants in cells, is catalyzed by peroxidase to oxidized glutathione (GSSG) during lipid peroxidation, and inhibit lipid peroxidation-induced ferroptosis (119)

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Such designs are not representative of the clinical scenario, in which patients present with established, symptomatic disease

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