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Rachel Halverson, RN, CDCES, NC-BC explains that metformin is typically considered the first-line of treatment for T2D and is widely used due to its long history of effectiveness, safety, and low cost. It works primarily by reducing glucose production in the liver and improving the bodys insulin sensitivity

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Side effects and safety profile Across the combined Phase 3 Tesamorelin database of over 800 treated subjects, the most frequently reported adverse events were injection site reactions (erythema, pruritus, small local hematoma) at roughly 25 percent of subjects, arthralgia and myalgia at 10 to 15 percent, and peripheral edema at 6 to 8 percent

If you are already on spironolactone, the provider can tailor your semaglutide or tirzepatide protocol to ensure your safety