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6,7 Long-term trials evaluating the effects on the immune system may be warranted owing to increased reports of nasopharyngitis, urinary tract infection, and small elevations in white blood cell count

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These cells normally exist in a quiescent state but become activated following muscle injury or mechanical stimulation, proliferating and fusing with existing muscle fibers to support hypertrophy and repair

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This hydrolytic enzyme is encoded by the ASAH2 gene which is critical in ceramide metabolism [51]