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As I argued in the microdosing piece, GLP-1 receptors are on immune cells and blood vessel linings, not just fat, and some of the protection in obese people seems to begin before weight loss and persist beyond it (more on that in a second)

What is oral semaglutide, and how does it work for weight loss

Don't crush, chew, or split the tablet

It showed similar results: participants who took the drug lost an average of 15 percent of body weight lost, whereas those who took the placebo lost an average of just 2.4 percent

Pancreatitis symptoms, kidney disease or severe ongoing stomach pain

But they require close medical monitoring and a willingness to manage cost and side effects