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Increasing the dose without consulting your doctor can reduce GLP-1 effectiveness and increase side effects, such as severe nausea or vomiting, diarrhea or constipation, abdominal pain, or extreme loss of appetite 7

To mitigate this, a comprehensive weight management plan should include lifestyle modifications even after discontinuation

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18 Longer-acting GLP-1 RAs are associated with less robust effects on postprandial glucose and greater effects on fasting glucose

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