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Tresiba has been shown to be cardiovascular-safe (non-inferior to placebo) in the DEVOTE trial, but it has not demonstrated the cardiovascular benefit that GLP-1 medications provide
Some plans cover virtual doctor visits and prescription review
New or worsening symptoms after months of stable semaglutide therapy should also prompt evaluation, as these may not be medication-related
Estrogen fluctuations can make it difficult for the hypothalamus to regulate temperature, leading to hot flashes and facial, neck, and chest flushing
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![Structure of [ 3 H]liraglutide (top) and the GLP-1 receptor agonists](https://www.researchgate.net/profile/Inga-Bjornsdottir-2/publication/45650716/figure/fig2/AS:667822585806848@1536232720030/Structure-of-3-Hliraglutide-top-and-the-GLP-1-receptor-agonists-liraglutide-and.png)
