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To gain further insight, a non-compartmental PK analysis was performed using gPKPDSim 74 , which revealed a 3.8-fold slower clearance rate (CL) and a 2.4-fold longer mean residence time (MRT) of QMP compared with WT albumin (Supplementary Table 4)
The decrease in blood pressure during weight loss was not maintained during the weight loss period, but increased to the level before weight loss, even though the weight loss was maintained
Tirzepatide demonstrated superior weight loss outcomes
However, treatment with liraglutide was associated with a significant increase in serious cardiac side-effects (12 versus three
