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Furthermore, arginine depletion impaired T cells proliferation, mediated by GCN2 [19], and signaling downstream TCR due to downregulation of CD3 [89, 90]

Additionally, homocysteine would specifically inhibit inactivation of factor Va by activated protein C through homocysteinylation of the cofactor (Undas et al, 2001)

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Nishida Y, Ishizawa J, Ayoub E, Patsilevas T, Ostermann L, Heinz Montoya R, Muftuoglu M, Ruvolo V, Mak PY, Tao W, Carter BZ, Kojima K, Daver N, Lesegretain A, Seki T, Shacham S, Konopleva M, and Andreeff M

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Bardoxolone methyl improves kidney function in patients with chronic kidney disease stage 4 and type 2 diabetes: post-hoc analyses from bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes study