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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

Not surprisingly, a rise of the cobalamin concentration in serum is one of the diagnostic criteria for the latter two diseases

Future trials should examine both induction and maintenance therapy applications, biomarker responses, and endoscopic healing outcomes to establish clinical utility

However, there is a low risk of vitamin B12 toxicity because the body only utilizes what it needs and eliminates the excess

If a company wants approval for a new prescription or over-the-counter ingredient, the process can take decades